Edit the message. Rewrite the future.
Editing a single letter on RNA to modulate a biological pathway. Our mission is to deliver the promise of genetic medicines to complex prevalent diseases.
Ammonia: A Dangerous Waste Product
Ammonia is a natural byproduct of protein metabolism that must be efficiently removed from the body to prevent toxicity. When ammonia removal is disrupted, ammonia accumulates to dangerous levels in the blood, leading to hyperammonemia. Elevated ammonia levels can cause severe neurological symptoms, including confusion, seizures, coma, and potentially death, making effective ammonia management critical for patient survival and quality of life.
Two conditions where ammonia toxicity drives significant disease burden are urea cycle disorders and hepatic encephalopathy.
Our science
Our approach to edit RNA involves redirecting a naturally occurring editing process that’s inside every cell in the human body. This is accomplished by delivering a chemically modified RNA that helps to target precisely the change we want to make. Our proprietary platform called Oligonucleotide Promoted Editing of RNA (OPERA®) enables us to discover and develop these drug candidates.
Our pipeline
Our pipeline programs demonstrate the versatility of our approach in bringing precision and tunability to genetic medicines to address a broad range of rare and highly prevalent diseases. We can repair proteins caused by genetic mutations or alter proteins to activate a biological pathway.
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Career opportunities
Write the next chapter of your career with Korro, where we are developing a novel class of medicines.
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